THEMED ISSUE: CANNABINOIDS RESEARCH PAPER The plant cannabinoid D-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in micebph_756 677..687
نویسندگان
چکیده
1Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK, 2DBSF, Pharmacology Section and Neuroscience Centre, University of Insubria, Varese, Italy, 3Department of Biotechnology & Bioscience, University of Milano-Bicocca, Milano, Italy, 4Endocannabinoid Research Group, Division of Pharmacology ‘L Donatelli’, Department of Experimental Medicine, Second University of Naples, Naples, Italy and 5Endocannabinoid Research Group, Institute of Biomolecular Chemistry, CNR, Pozzuoli, Naples, Italy
منابع مشابه
Plant cannabinoids: a neglected pharmacological treasure trove.
Most of the cannabinoids in Cannabis sativa L. have not been fully evaluated for their pharmacological activity. A publication in this issue presents evidence that a plant cannabinoid, Delta(9)-tetrahydrocannabivarin is a potent antagonist of anandamide, a major endogenous cannabinoid. It seems possible that many of the non-psychoactive constituents of this plant will be of biological interest.
متن کاملNon-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.
Delta(9)-tetrahydrocannabinol binds cannabinoid (CB(1) and CB(2)) receptors, which are activated by endogenous compounds (endocannabinoids) and are involved in a wide range of physiopathological processes (e.g. modulation of neurotransmitter release, regulation of pain perception, and of cardiovascular, gastrointestinal and liver functions). The well-known psychotropic effects of Delta(9)-tetra...
متن کاملP 148: The Role of Cannabinoids in Ischemia Stroke
Inflammation serves a protective function in controlling infections and promoting tissue repair, and can also cause damage to tissue and disease. Many types of cells involved in this process, expressing the components of the cannabinoid signaling system that can be controlled endogenously or pharmacologically. Cannabinoids inhibit neuroinflammation and the immune cells express the whole machi...
متن کاملTHEMED ISSUE: CANNABINOIDS REVIEW Phytocannabinoids beyond the Cannabis plant – do they exist?bph_745 523..529
It is intriguing that during human cultural evolution man has detected plant natural products that appear to target key protein receptors of important physiological systems rather selectively. Plants containing such secondary metabolites usually belong to unique chemotaxa, induce potent pharmacological effects and have typically been used for recreational and medicinal purposes or as poisons. C...
متن کاملThe Cannabinoids Δ8THC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation
Background and Purpose: Corneal injury can result in dysfunction of corneal nociceptive signaling and corneal sensitization. Activation of the endocannabinoid system has been reported to be analgesic and anti-inflammatory. The purpose of this research was to investigate the antinociceptive and anti-inflammatory effects of cannabinoids with reported actions at cannabinoid 1 (CB1R) and cannabinoi...
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تاریخ انتشار 2010